{"id":2936,"date":"2026-10-26T19:06:11","date_gmt":"2026-10-26T19:06:11","guid":{"rendered":"https:\/\/admarebio.com\/?p=2936"},"modified":"2026-11-02T15:21:19","modified_gmt":"2026-11-02T15:21:19","slug":"specific-biologics","status":"publish","type":"post","link":"https:\/\/admarebio.com\/fr\/nouvelles-et-evenements\/actualites-et-perspectives\/specific-biologics\/","title":{"rendered":"Specific Biologics"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\">Pr\u00e9sentation de l&#8217;entreprise<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Soci\u00e9t\u00e9 de biotechnologie bas\u00e9e \u00e0 Toronto, qui d\u00e9veloppe une plateforme d\u2019\u00e9dition g\u00e9nomique de nouvelle g\u00e9n\u00e9ration destin\u00e9e au traitement de maladies g\u00e9n\u00e9tiques neurologiques et neuromusculaires graves, telles que la scl\u00e9rose lat\u00e9rale amyotrophique (SLA) et la maladie de Huntington.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Technologie : Plateforme<\/li>\n\n\n\n<li>Modalit\u00e9 : Th\u00e9rapie g\u00e9nique administr\u00e9e par voie non virale, sous forme d\u2019ARN messager (ARNm), ou au moyen d\u2019un vecteur viral ad\u00e9no-associ\u00e9 (AAV) unique.<\/li>\n\n\n\n<li>Stade de d\u00e9veloppement : Pr\u00e9clinique<\/li>\n<\/ul>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Pourquoi cette entreprise est-elle importante ?<\/h3>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-794e3cfa wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Specific Biologics d\u00e9veloppe une technologie d\u2019\u00e9dition g\u00e9nomique de nouvelle g\u00e9n\u00e9ration, appel\u00e9e Dualase\u00ae, qui repose sur un m\u00e9canisme ciblant deux sites afin de corriger avec pr\u00e9cision les s\u00e9quences d\u2019ADN responsables de maladies, tout en limitant les modifications g\u00e9n\u00e9tiques involontaires.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cette approche novatrice vise \u00e0 surmonter certaines limites importantes des technologies d\u2019\u00e9dition g\u00e9nomique existantes en mati\u00e8re de s\u00e9curit\u00e9 et d\u2019efficacit\u00e9.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">La plateforme pourrait permettre de traiter un large \u00e9ventail de maladies g\u00e9n\u00e9tiques. Dans un premier temps, Specific Biologics se concentre sur les maladies caus\u00e9es par des expansions anormales de r\u00e9p\u00e9titions dans l\u2019ADN, avec un premier programme ciblant une forme g\u00e9n\u00e9tique de la scl\u00e9rose lat\u00e9rale amyotrophique (SLA).<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/admarebio.com\/fr\/developper-des-compagnies\/portefeuille\/\">Voir nos autres companies portfolio  <\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full has-custom-border\"><img loading=\"lazy\" decoding=\"async\" width=\"719\" height=\"379\" src=\"https:\/\/admarebio.com\/wp-content\/uploads\/2026\/10\/specific-biologics-2.jpg\" alt=\"\" class=\"has-border-color has-admare-blue-border-color wp-image-2899\" style=\"border-width:3px;border-top-left-radius:48px;border-top-right-radius:48px;border-bottom-left-radius:48px;border-bottom-right-radius:48px\"\/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:13px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Le r\u00f4le d&#8217;adMare?<\/h3>\n\n\n\n<div class=\"wp-block-group is-style-default has-border-color has-cobalt-border-color has-glacier-background-color has-background wp-elements-1 is-layout-constrained wp-container-core-group-is-layout-d4c2d7a2 wp-block-group-is-layout-constrained\" style=\"border-width:2px;border-top-left-radius:10px;border-top-right-radius:10px;border-bottom-left-radius:10px;border-bottom-right-radius:10px;padding-top:0;padding-right:0;padding-bottom:0;padding-left:0\">\n<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center has-large-font-size\" style=\"font-weight:700;line-height:1.2\"><strong style=\"font-weight: bold;\">Validation<\/strong><\/h2>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-indigo-color has-text-color has-link-color wp-elements-2 is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-8f7a88a5 wp-block-group-is-layout-constrained\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\">\n<ul class=\"wp-block-list\">\n<li><strong>Valorisation de la recherche universitaire <\/strong>: La plateforme d\u2019\u00e9dition g\u00e9nomique Dualase\u00ae de Specific Biologics repose sur les travaux de recherche novateurs du Dr David Edgell, men\u00e9s \u00e0 la Western University.<br><\/li>\n\n\n\n<li><strong>Validation scientifique et commerciale <\/strong>: adMare a travaill\u00e9 avec l\u2019\u00e9quipe fondatrice afin d\u2019\u00e9valuer les avantages diff\u00e9renciants de la technologie Dualase\u00ae et son potentiel commercial. Cette d\u00e9marche a conduit \u00e0 l\u2019\u00e9laboration d\u2019un plan de R&amp;D cibl\u00e9, destin\u00e9 \u00e0 valider le potentiel de cette plateforme technologique sur plusieurs cibles th\u00e9rapeutiques prometteuses.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-style-default has-border-color has-cobalt-border-color has-glacier-background-color has-background wp-elements-3 is-layout-constrained wp-container-core-group-is-layout-d4c2d7a2 wp-block-group-is-layout-constrained\" style=\"border-width:2px;border-top-left-radius:10px;border-top-right-radius:10px;border-bottom-left-radius:10px;border-bottom-right-radius:10px;padding-top:0;padding-right:0;padding-bottom:0;padding-left:0\">\n<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center has-large-font-size\" style=\"font-weight:700;line-height:1.2\"><strong style=\"font-weight: bold;\">Incubation<\/strong><\/h2>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-indigo-color has-text-color has-link-color wp-elements-4 is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-8f7a88a5 wp-block-group-is-layout-constrained\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\">\n<ul class=\"wp-block-list\">\n<li><strong>Investissement d\u2019amor\u00e7age et constitution du syndicat d\u2019investisseurs <\/strong>: D\u00e8s les premi\u00e8res \u00e9tapes, adMare a attir\u00e9 Lumira Ventures dans cette opportunit\u00e9 d\u2019investissement. Les deux soci\u00e9t\u00e9s ont codirig\u00e9 le financement d\u2019amor\u00e7age de Specific Biologics, apportant les capitaux n\u00e9cessaires \u00e0 la mise en \u0153uvre du plan de validation en R&amp;D.<br><\/li>\n\n\n\n<li><strong>Mise en \u0153uvre de la R&amp;D et r\u00e9duction des risques <\/strong>: \u00c0 la suite de ce financement d\u2019amor\u00e7age, adMare a collabor\u00e9 \u00e9troitement avec l\u2019entreprise \u00e0 la r\u00e9alisation de ce programme de validation pluriannuel. Celui-ci a \u00e9valu\u00e9 six cibles th\u00e9rapeutiques \u00e0 l\u2019aide d\u2019essais in vitro et de mod\u00e8les animaux. Ces travaux ont permis d\u2019identifier la SLA comme programme prioritaire de l\u2019entreprise et de g\u00e9n\u00e9rer des donn\u00e9es essentielles de preuve de concept et d\u2019efficacit\u00e9, n\u00e9cessaires pour attirer des investisseurs dans le cadre d\u2019un financement de s\u00e9rie A.<br><\/li>\n\n\n\n<li><strong>Accompagnement op\u00e9rationnel <\/strong>: adMare a apport\u00e9 son expertise scientifique, son soutien en gestion de projet, ses conseils strat\u00e9giques et son accompagnement en mati\u00e8re de gouvernance, tandis que Specific Biologics d\u00e9veloppait sa plateforme et renfor\u00e7ait ses capacit\u00e9s internes.<br><\/li>\n\n\n\n<li><strong>D\u00e9veloppement des talents<\/strong> : Gr\u00e2ce au programme de bourses postdoctorales ASCEND d\u2019adMare, Specific Biologics a pu renforcer son \u00e9quipe scientifique en recrutant un talent hautement qualifi\u00e9 pour faire avancer ses priorit\u00e9s cl\u00e9s en R&amp;D. adMare a pris en charge 50 % de la r\u00e9mun\u00e9ration du chercheur postdoctoral, ainsi que le recrutement, l\u2019int\u00e9gration et l\u2019accompagnement dans le d\u00e9veloppement du leadership. Ce soutien a permis \u00e0 l\u2019entreprise de renforcer ses capacit\u00e9s et de pr\u00e9server ses ressources financi\u00e8res tout en faisant progresser ses programmes de d\u00e9veloppement et en contribuant \u00e0 former la prochaine g\u00e9n\u00e9ration de talents canadiens dans le secteur des sciences de la vie.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-style-default has-border-color has-cobalt-border-color has-glacier-background-color has-background wp-elements-5 is-layout-constrained wp-container-core-group-is-layout-d4c2d7a2 wp-block-group-is-layout-constrained\" style=\"border-width:2px;border-top-left-radius:10px;border-top-right-radius:10px;border-bottom-left-radius:10px;border-bottom-right-radius:10px;padding-top:0;padding-right:0;padding-bottom:0;padding-left:0\">\n<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center has-large-font-size\" style=\"font-weight:700;line-height:1.2\"><strong style=\"font-weight: bold;\"><strong>Acc\u00e9l\u00e9ration<\/strong><\/strong><\/h2>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-indigo-color has-text-color has-link-color wp-elements-6 is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-8f7a88a5 wp-block-group-is-layout-constrained\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\">\n<ul class=\"wp-block-list\">\n<li><strong>Investissement et syndication de s\u00e9rie A <\/strong>: adMare a particip\u00e9 au financement de s\u00e9rie A de Specific Biologics, d\u2019un montant de 35 millions de dollars am\u00e9ricains (49 millions de dollars canadiens), t\u00e9moignant ainsi de sa confiance renouvel\u00e9e dans l\u2019entreprise et contribuant \u00e0 mobiliser un solide syndicat d\u2019investisseurs. Ce tour de financement a renforc\u00e9 la participation canadienne au capital de l\u2019entreprise, gr\u00e2ce \u00e0 la poursuite de l\u2019investissement de Lumira Ventures, ainsi qu\u2019\u00e0 l\u2019arriv\u00e9e de nouveaux investisseurs nationaux : Genesys Capital, le Fonds de capital-risque en sciences de la vie de la BDC et Seido Capital. Men\u00e9 par l\u2019investisseur am\u00e9ricain Hatteras Venture Partners, ce financement a \u00e9galement permis d\u2019attirer des capitaux et une expertise \u00e0 l\u2019\u00e9chelle internationale.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:19px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Les prochaines \u00e9tapes?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Le financement de s\u00e9rie A permettra de soutenir les travaux n\u00e9cessaires en mati\u00e8re de s\u00e9curit\u00e9, de fabrication et de r\u00e9glementation afin de faire progresser le programme prioritaire de Specific Biologics contre la SLA vers un premier essai clinique chez l\u2019humain.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">L\u2019entreprise poursuivra \u00e9galement ses d\u00e9marches en vue de conclure des partenariats et de d\u00e9velopper d\u2019autres applications de la plateforme Dualase\u00ae, ouvrant ainsi la voie au traitement d\u2019autres maladies g\u00e9n\u00e9tiques graves.<\/p>\n\n\n\n<div style=\"height:19px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Les retomb\u00e9es pour le Canada?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">adMare a contribu\u00e9 \u00e0 transformer une technologie novatrice issue de la Western University en une entreprise canadienne de biotechnologie pr\u00eate \u00e0 attirer des investissements. En combinant des capitaux nationaux \u00e0 un accompagnement scientifique, op\u00e9rationnel et humain, adMare a aid\u00e9 Specific Biologics \u00e0 produire les donn\u00e9es et les preuves n\u00e9cessaires pour attirer des investissements importants, tant au Canada qu\u2019\u00e0 l\u2019international.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Les progr\u00e8s de l\u2019entreprise d\u00e9montrent comment un accompagnement cibl\u00e9 d\u00e8s les premi\u00e8res \u00e9tapes de d\u00e9veloppement peut permettre de cr\u00e9er des emplois hautement qualifi\u00e9s, de renforcer l\u2019expertise canadienne dans le domaine des technologies de pointe en \u00e9dition g\u00e9nomique et de maintenir davantage de propri\u00e9t\u00e9 intellectuelle et de valeur \u00e9conomique au Canada.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cette lev\u00e9e de fonds de s\u00e9rie A constitue \u00e9galement l\u2019un des premiers investissements du nouveau Fonds des sciences de la vie de la BDC. Elle souligne ainsi le r\u00f4le essentiel d\u2019adMare dans la constitution d\u2019un solide vivier d\u2019entreprises canadiennes attractives pour les investisseurs et pr\u00eates \u00e0 b\u00e9n\u00e9ficier de nouvelles sources de capitaux nationaux pour soutenir leur croissance.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pr\u00e9sentation de l&#8217;entreprise Soci\u00e9t\u00e9 de biotechnologie bas\u00e9e \u00e0 Toronto, qui d\u00e9veloppe une plateforme d\u2019\u00e9dition g\u00e9nomique de nouvelle g\u00e9n\u00e9ration destin\u00e9e au traitement de maladies g\u00e9n\u00e9tiques neurologiques et neuromusculaires graves, telles que [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":2938,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[155],"tags":[],"company":[123],"class_list":["post-2936","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-etude-de-cas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Specific Biologics | adMare<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/admarebio.com\/fr\/nouvelles-et-evenements\/actualites-et-perspectives\/specific-biologics\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Specific Biologics | adMare\" \/>\n<meta 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