{"id":1700,"date":"2025-02-19T13:08:04","date_gmt":"2025-02-19T13:08:04","guid":{"rendered":"https:\/\/admarebio.com\/news-events\/news-insights\/"},"modified":"2026-06-26T18:41:28","modified_gmt":"2026-06-26T18:41:28","slug":"epitopea-announces-nature-cancer-paper-on-novel-immunotherapy-targets-in-melanoma-and-nsclc","status":"publish","type":"post","link":"https:\/\/admarebio.com\/news-events\/news-insights\/epitopea-announces-nature-cancer-paper-on-novel-immunotherapy-targets-in-melanoma-and-nsclc\/","title":{"rendered":"Epitopea Announces Nature Cancer Paper on Novel Immunotherapy Targets in Melanoma and NSCLC"},"content":{"rendered":"\n<p><strong>Further Validates Cryptigens<sup>TM<\/sup>&nbsp;as Actionable Targets for Cancer Immunotherapy<\/strong><\/p>\n\n\n\n<p><strong>Montreal, Quebec, &amp; Cambridge, UK, 27 May 2025&nbsp;<\/strong>\u2013 Epitopea, a transatlantic cancer immunotherapy company, and Institute for Research in Immunology and Cancer (IRIC) of the Universit\u00e9 de Montr\u00e9al, a leading Canadian research institution renowned for scientific innovation and technology transfer, announce a scientific publication in the leading medical journal Nature Cancer (1). This paper demonstrates that Epitopea\u2019s CryptoMap<sup>TM<\/sup>&nbsp;platform can identify shared, nonmutated, aberrantly-expressed tumor-specific antigens (Cryptigens<sup>TM<\/sup>) as highly abundant, actionable targets for immunotherapy in melanoma and non-small cell lung cancer (NSCLC). The identification of Cryptigens<sup>TM<\/sup>&nbsp;with potential clinical utility distinguishes Epitopea\u2019s approach from many other immunotherapy companies that have focused on the identification of mutated tumor antigens (mTAs).<\/p>\n\n\n\n<p>In the paper, produced with international academic collaborators at Canada\u2019s McGill University, University of Liege in Belgium, and Switzerland\u2019s University of Lausanne, CryptoMap<sup>TM<\/sup>&nbsp;identified 589 non-redundant tumor antigens (TAs) in cutaneous melanoma and NSCLC. Significantly, only 1% of the actionable TAs were derived from mutated sequences or mTAs. Of the 99% of TAs remaining, approximately 37% (n=220) of TAs identified were Cryptigens<sup>TM<\/sup>. These Cryptigens<sup>TM<\/sup>&nbsp;are immunogenic, shared among tumor samples, and could contribute to immune checkpoint blockade responses, supporting their utility in immune targeting across the tumor landscape.<\/p>\n\n\n\n<p>\u201c<em>These data from this latest publication from our collaborators at UdeM further validate the potential benefit of Epitopea\u2019s CryptoMap<sup>TM<\/sup>&nbsp;platform and our transformative approach to treating cancer<\/em>,\u201d commented Epitopea\u2019s CEO, Alan C. Rigby. \u201c<em>We believe our Cryptigens<sup>TM<\/sup>&nbsp;offer significant competitive advantages over current treatment approaches that have focused solely on mTAs.&nbsp; As illustrated, our approach has the potential to stimulate the immune system to precisely recognize and destroy cancer cells more rapidly and effectively, which we believe will translate into durable patient responses in these indications.\u201d<\/em><\/p>\n\n\n\n<p>&#8220;<em>We have long been researching immune-based approaches that could transform the lives of cancer patients through the discovery of accessible and effective immunotherapies for difficult-to-treat tumors. This latest research further strengthens our understanding of the target space amenable for the development of cancer immunotherapy treatments. In particular, the fact that only 1% of tumor antigens are derived from mutated sequences highlights the potential value of exploring unmutated sequences across the cancer landscape. Collectively, the findings in our collaborative manuscript challenge a dogmatic belief that mTAs are the dominant actionable targets for cancer immunotherapy,<\/em>&#8221; said Dr. Claude Perreault, Principal Investigator at UdeM\u2019s Institute for Research in Immunology and Cancer, corresponding author of the paper, and a co-founder of Epitopea.<\/p>\n\n\n\n<p>Reference:<br>(1) Nature Cancer paper: \u201c<a href=\"https:\/\/www.nature.com\/articles\/s43018-025-00979-2\" rel=\"noreferrer noopener\" target=\"_blank\">Tumor antigens preferentially derive from unmutated genomic sequences in melanoma and non-small cell lung cancer<\/a>\u201d.<\/p>\n\n\n\n<p><strong><u>About Epitopea<\/u><\/strong><br>Epitopea is a transatlantic cancer immunotherapeutics company developing accessible off-the-shelf RNA-based immunotherapies for use in hard-to-treat cancers by targeting a new class of untapped tumor-specific antigens, which are known as Cryptigen<sup>TM<\/sup>&nbsp;TSAs, that are broadly shared across multiple patients with the same tumor type.&nbsp;<\/p>\n\n\n\n<p>The company has created an extensive library of novel Cryptigen<sup>TM&nbsp;<\/sup>TSAs, discovered by its proprietary CryptoMap<sup>TM<\/sup>&nbsp;platform that leverages immunopeptidomics, genomics, and a bioinformatics pipeline, allowing the identification of aberrantly-expressed, tumor-specific antigens (aeTSAs) that are hidden within cancer\u2019s \u2019junk\u2019 DNA.&nbsp; These hidden Cryptigen<sup>TM<\/sup>&nbsp;TSAs were first discovered through research led by Drs. Claude Perreault and Pierre Thibault at the Institute for Research in Immunology and Cancer at the Universit\u00e9 de Montr\u00e9al.<\/p>\n\n\n\n<p>Epitopea is backed by leading life science investors including Advent Life Sciences, CTI Life Sciences, Cambridge Innovation Capital, Le Fonds de Solidarit\u00e9 FTQ, Investissement Qu\u00e9bec, adMare BioInnovations, Jonathan Milner, the Harrington Discovery Institute, IRICoR and Novateur Ventures. The company has a license and research collaboration with MSD (tradename of Merck &amp; Co., Inc., Rahway, N.J., USA).<\/p>\n\n\n\n<p>Epitopea was founded in 2021 and consists of sister companies based in Cambridge, UK and in Montreal, Canada. For additional information, please visit&nbsp;<a href=\"http:\/\/www.epitopea.com\/\">www.epitopea.com<\/a>&nbsp;and follow us on&nbsp;<a href=\"https:\/\/www.linkedin.com\/company\/epitopea\" rel=\"noreferrer noopener\" target=\"_blank\">LinkedIn<\/a>.<\/p>\n\n\n\n<p><strong>About the Institute for Research in Immunology and Cancer (IRIC) of the Universit\u00e9 de Montr\u00e9al<\/strong><\/p>\n\n\n\n<p>An ultra-modern research hub and training centre located in the heart of the Universit\u00e9 de Montr\u00e9al, the Institute for Research in Immunology and Cancer of the Universit\u00e9 de Montr\u00e9al was created in 2003 to shed light on the mechanisms of cancer and discover new, more effective therapies to counter this disease. The IRIC operates according to a model that is unique in Canada. Its innovative approach to research has already led to discoveries that will, over the coming years, have a significant impact on the fight against cancer.<\/p>\n\n\n\n<p><strong>For further information<\/strong><\/p>\n\n\n\n<p><strong>Epitopea<\/strong><br>Dr. Alan C. Rigby \u2013 CEO<br><a href=\"mailto:Alan.Rigby@epitopea.com\">Alan.Rigby@epitopea.com<\/a><\/p>\n\n\n\n<p><strong>Scius Communications&nbsp;(for Epitopea)<\/strong><br>Katja Stout<br>+44 7789 435990<br><a href=\"mailto:katja@sciuscommunications.com\">katja@sciuscommunications.com<\/a><\/p>\n\n\n\n<p>Daniel Gooch<br>+44 7747 875479<br><a href=\"mailto:daniel@sciuscommunications.com\">daniel@sciuscommunications.com<\/a><\/p>\n\n\n\n<p><strong>No\u00e9mie Desbois Mackenzie<\/strong><br>Communication Manager<br>IRIC<br>+1 514-475-7682<br><a href=\"mailto:noemie.desbois.mackenzie@umontreal.ca\">noemie.desbois.mackenzie@umontreal.ca<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/www.epitopea.com\/epitopea-announces-nature-cancer-paper-on-novel-immunotherapy-targets-in-melanoma-and-nsclc\/\">Read the official press release<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Further Validates CryptigensTM&nbsp;as Actionable Targets for Cancer Immunotherapy Montreal, Quebec, &amp; Cambridge, UK, 27 May 2025&nbsp;\u2013 Epitopea, a transatlantic cancer immunotherapy company, and Institute for Research in Immunology and Cancer [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":1617,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[29],"tags":[],"company":[78],"class_list":["post-1700","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-portfolio-companies"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Epitopea Announces Nature Cancer Paper on Novel Immunotherapy Targets in Melanoma and NSCLC | adMare<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta 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