{"id":1616,"date":"2026-04-23T19:04:16","date_gmt":"2026-04-23T19:04:16","guid":{"rendered":"https:\/\/admarebio.com\/news-events\/news-insights\/"},"modified":"2026-06-26T13:07:30","modified_gmt":"2026-06-26T13:07:30","slug":"epitopea-announces-approval-of-ovact-clinical-trial-application-for-cryptivax-1001-in-advanced-high-grade-serous-ovarian-cancer","status":"publish","type":"post","link":"https:\/\/admarebio.com\/news-events\/news-insights\/epitopea-announces-approval-of-ovact-clinical-trial-application-for-cryptivax-1001-in-advanced-high-grade-serous-ovarian-cancer\/","title":{"rendered":"Epitopea Announces Approval of OVACT Clinical Trial Application for CryptiVax-1001 in Advanced High-Grade Serous Ovarian Cancer"},"content":{"rendered":"\n

CAMBRIDGE, UK and MONTREAL, CANADA, 23 April 2026<\/strong> \u2013 Epitopea, a transatlantic biotech developing off-the-shelf, durable, RNA-based cancer immunotherapies, today announced that it has received approval from the UK\u2019s Medicines and Healthcare products Regulatory Agency (MHRA) and the Regional Ethics Committee (REC) for its clinical trial application (CTA) for its first-in-human clinical trial (OVACT) of its lead program, CryptiVax\u2122-1001, targeting advanced high-grade serous ovarian cancer. <\/p>\n\n\n\n

Epitopea also announces the appointment of Professor Susana Banerjee (MBBS MA PhD FRCP), a Consultant Medical Oncologist and Research Lead for the Gynaecology Unit at\u202fThe Royal Marsden<\/a> NHS Foundation Trust and Professor in Women\u2019s Cancers at the Institute of Cancer Research, as Chief Investigator of the OVACT trial.<\/p>\n\n\n\n

Dr. Klaus Edvardsen, MD, Chief Medical Officer of Epitopea, commented, \u201cWe are excited by the achievement of this significant regulatory milestone, which is a credit to our dedicated clinical and wider Epitopea team. We also welcome Professor Banerjee to her role as Chief Investigator of our first clinical trial. Her world-class expertise in ovarian cancer and leadership in global clinical development will bring invaluable insights as we transition to a clinical-stage company.\u201d<\/p>\n\n\n\n

OVACT is a Phase 1\/1b dose escalation and expansion trial designed to evaluate the safety, tolerability, immunogenicity, and early clinical activity of CryptiVax\u2122-1001 in HRP+\/BRCA-wildtype high-grade serous ovarian cancer patients. <\/p>\n\n\n\n

High-Grade Serous Ovarian Cancer(HGSOC) remains one of the most difficult-to-treat solid tumors, with most patients (~80%) presenting with advanced or metastatic disease. While most women respond to first-line platinum chemotherapy, nearly all ultimately relapse and progress to platinum-resistant disease. Existing maintenance options leave a major therapeutic gap among HRP+\/BRCA-wildtype patients, who represent roughly half of the ovarian cancer population. <\/p>\n\n\n\n

Professor Banerjee added: \u201cThere is a substantial unmet need in homologous recombination proficient (HRP) ovarian cancer, where available maintenance therapies deliver limited durable benefit. Epitopea\u2019s CryptiVax\u2122-1001 vaccine, which targets a novel repertoire of tumor-specific antigens, has the potential to meaningfully extend remission for patients with few effective treatment options.\u201d <\/p>\n\n\n\n

Epitopea\u2019s pipeline is enabled by CryptoMapTM<\/sup>, a proprietary discovery engine that identifies tumor-presented antigens arising from the dark genome, a previously inaccessible source of novel, tumor-specific targets. These antigens, known as CryptigensTM<\/sup>, demonstrate high inter-patient sharing, enabling development of true off-the-shelf mRNA immunotherapies. <\/p>\n\n\n\n

About Epitopea<\/strong> 
Epitopea is a transatlantic cancer immunotherapeutics company developing accessible, off-the-shelf RNA-based immunotherapies for hard-to-treat solid tumors. Epitopea\u2019s pipeline is built on Cryptigen\u2122 TSAs, a new class of tumor-specific antigens identified by CryptoMap\u2122, the company\u2019s proprietary immunopeptidomics and genomics platform that uncovers aberrantly expressed antigens arising from previously uncharacterised regions of the genome. <\/p>\n\n\n\n

The company\u2019s lead candidate, CryptiVax\u2122-1001, is an off-the-shelf mRNA therapeutic vaccine in development for high-grade serous ovarian cancer. It is designed to drive targeted immune responses using a set of tumor-specific antigens chosen for broad patient coverage. Many patients with advanced cancers, including high-grade serous ovarian cancer, have limited durable treatment options and few effective therapies beyond biomarker-selected populations. Epitopea aims to address this unmet need with broadly applicable, tumor-selective immunotherapies.
 
Backed by leading life-science investors, Epitopea operates from Cambridge, UK, and Montreal, Canada. For more information, visit\u202fwww.epitopea.com<\/strong><\/a>\u202fand follow the company on\u202fLinkedIn<\/strong><\/a>. <\/p>\n\n\n\n

For further information<\/strong> 
Epitopea\u202f<\/strong> 
Dr. Alan C. Rigby \u2013 CEO\u202f 
Alan.Rigby@epitopea.com<\/a> <\/p>\n\n\n\n

Scius Communications\u202f(for Epitopea)\u202f<\/strong> 
Katja Stout\u202f 
+44 7789 435990\u202f 
katja@sciuscommunications.com<\/a> <\/p>\n\n\n\n

Daniel Gooch\u202f 
+44 7747 875479\u202f 
daniel@sciuscommunications.com<\/a> <\/p>\n","protected":false},"excerpt":{"rendered":"

CAMBRIDGE, UK and MONTREAL, CANADA, 23 April 2026 \u2013 Epitopea, a transatlantic biotech developing off-the-shelf, durable, RNA-based cancer immunotherapies, today announced that it has received approval from the UK\u2019s Medicines and Healthcare products Regulatory Agency (MHRA) and the Regional Ethics Committee (REC) for its clinical trial application (CTA) for its first-in-human […]<\/p>\n","protected":false},"author":4,"featured_media":1617,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[29],"tags":[],"company":[78],"class_list":["post-1616","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-portfolio-companies"],"yoast_head":"\nEpitopea Announces Approval of OVACT Clinical Trial Application for CryptiVax-1001 in Advanced High-Grade Serous Ovarian Cancer | adMare<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, 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